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TLR7/8 agonist 8

SKU: orb1944362

Description

Compound 24m is a potent dual TLR7/8 agonist with EC50 values of 27 nM (hTLR7) and 12 nM (hTLR8). It is utilized in immuno-oncology research to study innate immune activation and has been shown in published studies to synergize with PD-1/PD-L1 blockade in preclinical tumor models.

Research Area

Immunology & Inflammation, Pharmacology & Drug Discovery; Cell Biology

Images & Validation

Key Properties

CAS Number2649170-16-9
MW418.53
FormulaC24H30N6O
SMILESC(N1CC2(C1)COC2)C3=CC=C(CC4=NC5=C(C=C4)N=C(N)N=C5NCCCC)C=C3
TargetOthers,TLR

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Key Properties

No computed properties available.

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Protocol Information

TLR7/8 agonist 8 (orb1944362)

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25 mg
$ 2,010.00
50 mg
$ 2,620.00
100 mg
$ 3,440.00
DispatchUsually dispatched over 10 weeks
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