TLR7 agonist 2

SKU: orb1303015

Description

TLR7 agonist 2

Research Area

Immunology & Inflammation

Key Properties

• CAS Number: 1642857-69-9
• MW: 336.35
• Purity: 98.98%
• Formula: C₁₇H₁₆N₆O₂
• SMILES: Cc1cc(COc2nc(N)nc3ccn(Cc4ccccn4)c23)no1
• Target: TLR
• Solubility: DMSO:45 mg/mL (133.79 mM)

Bioactivity

• Target IC50:
  TLR7:LEC: 0.4 μM
• Cell Research:
  The ability of TLR7-agonist-1 to activate human TLR7 and/or TLR8 is assessed by using HEK293 cells. Briefly, HEK293 cells are grown in culture medium (DMEM supplemented with 10% FCS and 2 mM Glutamine). Transfected cells are then detached with Trypsin-EDTA, washed in PBS and resuspended in medium to a density of 1.6 × 05 cells/mL. Thirty microliters of cells are then dispensed into Each well in 384-well plates, where 10 μL of TLR7-agonist-1 in 4% DMSO is already present. Following 6 hours incubation at 37℃, 5% CO2 the luciferase activity is determined by adding 15 μL of Steady Lite Plus substratee to each well and readout performed on a microplate imager. Lowest effective concentration (LEC) Values are determined for TLR7-agonist-1.
• Animal Research:
  In C57B-/- mice model Single oral administration of 0.3, 1, 3, and 10 mg/kg doses of TLR7-agonist-1.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

Inhibitor, inhibit, TLR7-IN-1, TLR7-agonist-1, TLR7 agonist 2, TLR-7 agonist 2, TLR7, TLR, Toll-like Receptor (TLR)

Compound Identifiers

PubChem CID

86346192