TGR5 agonist 9

SKU: orb3174938

Description

TGR5 agonist 9 is a highly selective, orally active allosteric agonist of TGR5, exhibiting EC₅₀ values of 0.48 μM for hTGR5 and 0.49 μM for mTGR5. It recruits β-arrestin 1 (EC₅₀= 78.8 μM) and β-arrestin 2 (EC₅₀= 12.3 μM), and demonstrates enhanced efficacy in cAMP accumulation (EC₅₀= 0.48 μM). In ICR mouse models, TGR5 agonist 9 shows significant hypoglycemic effects, making it a potential candidate for diabetes research.

Key Properties

• CAS Number: 2931879-67-1
• MW: 475.71
• Formula: C₂₉H₄₉NO₄
• SMILES: O(C)[C@H]1[C@]2([C@]3([C@@](C)([C@@]([C@@H](CCC(=O)N4CCCC4)C)(CC3)[H])[C@@H](O)C[C@@]2([C@]5(C)[C@](C1)(C[C@H](O)CC5)[H])[H])[H])[H]
• Target: GPCR19

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

GPCR19