STING Agonist D61

SKU: orb1980021

Description

D61 is a potent STING agonist with EC50 values of 52.9 nM and 116 nM for inducing IFN-β and SEAP reporter activity in vitro. It activates the TBK1-IRF3 pathway in monocytes and demonstrates in vivo antitumor efficacy in a CT26 colon cancer model at 0.25 mg/kg without weight loss.

Research Area

Immunology & Inflammation

Key Properties

• CAS Number: 2850251-27-1
• MW: 610.60
• Formula: C₂₉H₂₉F₃N₈O₄
• SMILES: COC1=C2C(N=C(NC(C3=CC(C)=NN3CC)=O)N2CCCNC4=NC=C(C5=C(C(F)(F)F)C=CC=C5)O4)=CC(C(N)=O)=C1
• Target: STING,Others

Storage & Handling

• Storage: -20°C
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

170915531