Sophoraflavanone G

SKU: orb1301311

Description

Sophoraflavanone G (Kushenol F) is a natural flavonoid from Sophora flavescens. It induces apoptosis in MDA-MB-231 breast cancer and HL-60 leukemia cells in vitro by suppressing MAPK signaling pathways, making it a candidate for oncology research.

Research Area

Cell Biology

Key Properties

• CAS Number: 97938-30-2
• MW: 424.49
• Purity: 99.88% (May vary between batches)
• Formula: C₂₅H₂₈O₆
• SMILES: CC(C)=CC[C@H](Cc1c(O)cc(O)c2C(=O)C[C@H](Oc12)c1ccc(O)cc1O)C(C)=C
• Target: Apoptosis
• Solubility: DMSO:145 mg/mL (341.59 mM)

Bioactivity

• Target IC50:
  MDA-MB-231 cells:29.7 μM (IC50)
• In Vitro:
  Sophoraflavanone G (0-100 μM; 24 hours) reduces HL-60 cell viability in a dose-dependent manner and induces apoptosis by activating caspase-3 and caspase-9, downregulating Bcl-2 and Bcl-xL, upregulating Bax, and releasing cytochrome c from mitochondria to cytoplasm, thus promoting apoptosis via the mitochondrially-mediated intrinsic pathway . Additionally, Sophoraflavanone G (0-40 μM; 24 hours) inhibits MDA-MB-231 cell viability with an IC50 of 29.7 μM in a concentration-dependent manner .

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

anti-infammatory, Apoptosis inducer, Apoptosis, HL60, inhibit, Inhibitor, Kushenol F, Vexibinol, Sophoraflavanone G

Compound Identifiers

PubChem CID

72936