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SGC-GAK-1

SKU: orb1221166

Description

SGC-GAK-1 is a selective cyclin G-associated kinase (GAK) inhibitor (Ki: 3.1 nM).

Images & Validation

Key Properties

CAS Number2226517-76-4
MW389.24
Purity>98% (HPLC)
FormulaC18H17BrN2O3
SMILESCOc1cc(Nc2ccnc3ccc(Br)cc23)cc(OC)c1OC
TargetGAK
SolubilityDMSO: 40 mg/mL;Ethanol: 15 mg/mL

Bioactivity

In Vitro
Cell Viability Assay Cell line: Prostate cancer cells (22Rv1, LNCaP, VCaP, PC3, DU145). Concentration: 0.1, 1, and 10 μM Incubation time: 48 hours or 72 hours. Result: Showed potent antiproliferative activity in LNCaP and 22Rv1 cells with IC50s of 0.05±0.15 μM and 0.17±0.65 μM, respectively.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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SGC-GAK-1 (orb1221166)

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Available Sizes

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200 mg
500 mg
5 mg
$ 130.00
10 mg
$ 190.00
25 mg
$ 350.00
50 mg
$ 540.00
100 mg
$ 780.00