Se-Methylselenocysteine

SKU: orb1299559

Description

Se-Methylselenocysteine (Se-MSC) is a well-studied organoselenium compound recognized for its chemopreventive properties. It functions by suppressing tumor promotion and triggering apoptosis, making it a valuable tool for cancer research in both cellular and animal models.

Research Area

Cell Biology, Metabolism Research, Neuroscience, Protein Biochemistry

Key Properties

• CAS Number: 26046-90-2
• MW: 182.08
• Purity: 99.87% (May vary between batches)
• Formula: C₄H₉NO₂Se
• SMILES: [C@H](C[Se]C)(C(O)=O)N
• Target: Caspase,Beta-Secretase,IAP,Bcl-2 Family,Apoptosis,Endogenous Metabolite
• Solubility: H2O:50.5 mg/mL (277.35 mM)

Bioactivity

• In Vivo:
  AD mice are treated with Se-Methylselenocysteine (0.75 mg kg-1 BW per day) in their drinking water for 10 months. Results reveal that Se-Methylselenocysteine 1) reduces oxidative stress and neuro-inflammation; 2) modulates the distribution and levels of several metal ions; 3) decreases amyloid-β peptide (Aβ) generation by inhibiting the expression of its precursor protein APP and β-secretase (BACE1); and 4) attenuates tau hyperphosphorylation and neurofibrillary tangles (NFT) formation via promoting protein phosphatase 2A (PP2A) activity, thereby preserving synaptic proteins and neuron activities and finally improving spatial learning and memory deficits in AD model mice.
• In Vitro:
  Se-Methylselenocysteine displayed strong inhibitory effects on cell proliferation and viability of SKOV-3 cells in dose and time dependent manners and induced apoptosis. Pretreatment of cells with the caspase inhibitors (z-VAD-fmk and DEVD-CHO) prevented Se-Methylselenocysteine-induced apoptosis. In late stage of apoptosis, p18kDa fragment of Bax was generated with the down-regulation of the expressions of survivin, X-linked inhibitor of apoptosis protein, and human inhibitor of apoptosis protein 1 following Se-Methylselenocysteine treatment. Pre-treatments of z-VAD-fmk and the calpain inhibitor, calpeptin inhibited Bax cleavage. Taken together, the chemopreventive effects of Se-Methylselenocysteine may be related in part to the caspase-3 activation, the down-regulation of IAP family proteins, and Bax cleavage mediated by caspase-dependent calpain activation.

Storage & Handling

• Storage: keep away from direct sunlight,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

SKOV-33, Se Methylselenocysteine, Se MSC, SeMSC, Se-MSC, SeMethylselenocysteine, Se-Methylselenocysteine, SeMCys, inhibit, MSeC, Methylselenocysteine, neck, orally, IAP, Inhibitor, head, FaDu, A253, Bax, cancer, Caspase-3, caspase-3, Apoptosis, cells, chemopreventive

Compound Identifiers

PubChem CID

147004