Sarcosine

SKU: orb1300297

Description

Sarcosine is a dual-function small molecule that competitively inhibits the glycine transporter GlyT1 and acts as a co-agonist at NMDA receptors. It is widely used in neuroscience research to study glutamatergic neurotransmission, synaptic plasticity, and related mechanisms in models of psychiatric and neurological disorders.

Research Area

Metabolism Research, Neuroscience

Key Properties

• CAS Number: 107-97-1
• MW: 89.09
• Purity: 99.90% (May vary between batches)
• Formula: C₃H₇NO₂
• SMILES: CNCC(O)=O
• Target: GlyT,Endogenous Metabolite
• Solubility: DMSO:Insoluble;H2O:250 mg/mL (2806.15 mM)

Bioactivity

• In Vivo:
  Sarcosine has weak anticonvulsant properties. It ameliorates (prepulse inhibition)PPI deficits in mGluR5 knockout mice.
• In Vitro:
  Sarcosine is a GlyR agonist in addition to being a GlyT1 inhibitor and NMDAR co-agonist, but it is less potent than glycine as a GlyR agonist and is not a full agonist. The viability of the sarcosine-treated cells is significantly reduced.
• Cell Research:
  Immediately after the cells grow to 50-60% confluence, the cultivation medium is replaced by fresh medium to synchronise cell growth. Cells are cultivated for 24 h under these conditions. Subsequently, the culture medium is supplemented with sarcosine (N-methylglycine) diluted to a final concentration 10, 150, 250, 500, 1,000 and 1,500 μM. Treatment is carried out for 0, 6, 12, 24 and 72 h, and samples are collected at these strictly defined time points.(Only for Reference)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

cognitive, depression, dysfunction, Endogenous Metabolite, Methylaminoacetic acid, Methylglycine, N-methyl-D-aspartate, N-methylglycine, N-Methylaminoacetic acid, inhibit, Inhibitor, Glycine transporters, GlyT, GlyT1, EndogenousMetabolite, Sarcosin, Sarcosine, Sarcosinic acid, schizophrenia

Compound Identifiers

PubChem CID

1088