(S)-CPI203

SKU: orb1301140

Description

CPI-203

Research Area

Cell Biology, Epigenetics & Chromatin

Key Properties

• CAS Number: 1446144-04-2
• MW: 399.9
• Purity: 99.66%
• Formula: C₁₉H₁₈ClN₅OS
• SMILES: Cc1nnc2[C@H](CC(N)=O)N=C(c3c(C)c(C)sc3-n12)c1ccc(Cl)cc1
• Target: Epigenetic Reader Domain,Apoptosis
• Solubility: DMSO:50 mg/mL (125.03 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5 mM)

Bioactivity

• Target IC50:
  BRD4:37 nM
• In Vitro:
  CPI203 inhibits BRD4 in vitro and in cells, while does not affect BRD4 kinase activity in vitro. CPI203 exerts a cytostatic effect in all the 9 MCL cell lines analyzed with GI50 ranging from 0.06 to 0.71 μM, with low cytotoxicity in normal PBMCs from healthy donors. Furthermore, lenalidomide and CPI203, by targeting IRF4 and MYC, efficiently activates the cell death program in MCL cells resistant to bortezomib.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

EpigeneticReaderDomain, Epigenetic Reader Domain, Inhibitor, inhibit, CPI 203, CPI203, CPI-203, BRD4, Apoptosis

Compound Identifiers

PubChem CID

71291068