Rotigotine Hydrochloride

SKU: orb1306357

Description

Rotigotine Hydrochloride (N-0924) is a potent dopamine agonist with high selectivity for D3 receptors and demonstrated anti-Parkinsonian activity. It is approximately 50 times more potent than quinpirole in vitro. This compound is widely used in preclinical research to study dopaminergic pathways in both cellular and animal models of Parkinson's disease.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 125572-93-2
• MW: 351.93
• Purity: 99.66% (May vary between batches)
• Formula: C₁₉H₂₆ClNOS
• SMILES: Cl.CCCN(CCc1cccs1)[C@H]1CCc2c(O)cccc2C1
• Target: 5-HT Receptor,Dopamine Receptor,Adrenergic Receptor
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.68 mM);DMSO:70 mg/mL (198.9 mM)

Bioactivity

• Target IC50:
  α2B-adrenoceptor:27 nM (Ki)|D4 receptor:4-15 nM (Ki)|5-HT1A receptor:30 nM (Ki)|α2A-adrenoceptor:338 nM (Ki)|D5 receptor:4-15 nM (Ki)|D2 receptor:4-15 nM (Ki)|α1A-adrenoceptor:176 nM (Ki)|5-HT7 receptor:86 nM (Ki)|D3 receptor:0.71 nM (Ki)|D1 receptor:83 nM (Ki)|α1B-adrenoceptor:273 nM (Ki)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Rotigotine, Rotigotine (Hydrochloride), Rotigotine HCl, Rotigotine Hydrochloride, Serotonin Receptor, α2B-adrenergic receptor, 5HTReceptor, 5-hydroxytryptamine Receptor, 5HT Receptor, 5-HT Receptor, Adrenergic Receptor, AdrenergicReceptor, Beta Receptor, D2, D3, D4, D5, D1, DopamineReceptor, Dopamine Receptor, Dopamine, N0923, N-0923, N0924, N-0924, N 0923, N 0924, inhibit, Inhibitor

Compound Identifiers

PubChem CID

180335