(R)-Equol

SKU: orb1940761

Description

(R)-Equol is an ERα and ERβ agonist with Kis of 27.4 and 15.4 nM, respectively.(In Vitro):(R)-Equol produced a dose-dependent inhibitory effect on the invasive ability of MDA-MB-231 cells, and this inhibitory effect was obvious at the highest test concentration (50 μM).Following 48-h exposure to (R)-Equol, invasion is reduced by 62% (p=0.009, versus untreated cells) with 50 μM (R)-Equol. Matrix metalloproteinase-2 (MMP-2) expression is significantly down-regulated following treatment with 50 μM (R)-Equol (p=0.035) .(In Vivo):In Animals, (R)-Equol has a significantly reduced number of palpable tumors over time when compared with Controls (P=0.002).In addition, the number of palpable tumors formed by each rat in the (R)-Equol fed group was significantly lower than that of rats treated with S-(-)equol (P = 0.008). (R)-Equol-fed animals have 43% fewer tumors than the control group and this difference is highly statistically significant (P=0.004). The number of tumors/tumor-bearing animals is significantly lower in the animals fed (R)-Equol compare with Controls (3.3±0.4 versus 5.5±0.5, P=0.004). At necropsy, the mean (±SEM) tumor weight per animal for (R)-Equol fed rats (5.3±1.1 mg) is significantly reduced (P=0.04) when compared with Controls (9.9±1.4 mg). Feeding the (R)-Equol diet results in significantly increased tumor latency (P=0.003) .

Key Properties

• CAS Number: 221054-79-1
• MW: 242.274
• Purity: >98% (HPLC)
• Formula: C₁₅H₁₄O₃
• SMILES: Oc1ccc(cc1)[C@@H]1COc2cc(O)ccc2C1
• Target: Estrogen Receptor/ERR
• Solubility: In Vitro: DMSO : 100 mg/mL (412.76 mM)

Bioactivity

• In Vivo:
  Animals fed (R)-Equol have a significantly reduced number of palpable tumors over time when compared with Controls (P = 0.002). Furthermore, the number of palpable tumors formed per rat in the (R)-Equol-fed group is significantly lower than that of rats treated with S-(-)equol (P = 0.008). (R)-Equol-fed animals have 43% fewer tumors than the control group and this difference is highly statistically significant (P = 0.004). The number of tumors/tumor-bearing animal is significantly lower in the animals fed (R)-Equol compared with Controls (3.3±0.4 versus 5.5±0.5, P = 0.004). At necropsy, the mean (±SEM) tumor weight per animal for (R)-Equol fed rats (5.3±1.1 mg) is significantly reduced (P = 0.04) when compared with Controls (9.9±1.4 mg). Feeding the (R)-Equol diet results in significantly increased tumor latency (P = 0.003).
• In Vitro:
  (R)-Equol is an agonist of both ERα and ERβ with Kis of 27.4 and 15.4 nM, respectively. (R)-Equol induces a dose-dependent inhibitory effect on the invasive capacity of MDA-MB-231 cells that is significant at the highest concentration tested (50 μM). Following 48-h exposure to (R)-Equol, invasion is reduced by 62% (p=0.009, versus untreated cells) with 50 μM (R)-Equol. Matrix metalloproteinase-2 (MMP-2) expression is significantly down-regulated following treatment with 50 μM (R)-Equol (p=0.035).

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

(+)-Equol

Quick Database Links

Gene Symbol

Estrogen Receptor/ERR