PRX-07034 hydrochloride

SKU: orb1298687

Description

PRX-07034 hydrochloride

Research Area

Neuroscience

Key Properties

• CAS Number: 903580-39-2
• MW: 490.44
• Purity: 99.17% (May vary between batches)
• Formula: C₂₁H₂₉Cl₂N₃O₄S
• SMILES: Cl.COc1cc(Cl)cc(C(C)Nc2cc(ccc2S(C)(=O)=O)N2CCNCC2)c1OC
• Target: 5-HT Receptor
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.04 mM);DMSO:10 mg/mL (20.39 mM)

Bioactivity

• Target IC50:
  5-HT1A receptor:420 nM (Ki)|μ opioid receptor:0.45 μM (Ki)|5-HT2B receptor:2.5 μM (IC50)|5-HT1D receptor:2.8 μM (Ki)|D3 receptor:71 nM (Ki)|H2 receptor:0.64 μM (Ki)|5-HT1B receptor:260 nM (Ki)|5-HT6 receptor:19 nM (IC50)|5-HT6 receptor:4-8 nM (Ki)|5-HT2C receptor:3.7 μM (IC50)|5-HT2A receptor:2.5 μM (IC50)
• In Vitro:
  PRX-07034 is a potent (Ki = 4-8 nM) and highly selective 5-HT(6) receptor antagonist with 100-fold selectivity over 68 other GPCRs, ion channels, and transporters, except for D(3) (Ki = 71 nM) and 5-HT(1B) (Ki = 260 nM) receptors. It demonstrated antagonist activity in cyclic AMP quantification (IC(50) = 19 nM) without affecting basal levels and showed no agonist activity up to 10 μM. At doses of 1 and 3 mg/kg, PRX-07034 significantly enhanced delayed spontaneous alternation and switching between place and response strategies, but did not affect initial learning of place or response discrimination.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

cognitive, 5HTReceptor, 5HT Receptor, 5-HT6, 5-HT Receptor, flexibility, memory, working, PRX 07034, PRX07034, PRX-07034, PRX-07034 HCL, PRX-07034 Hydrochloride

Compound Identifiers

PubChem CID

23653584