Ponatinib Hydrochloride

SKU: orb1703739

Description

Ponatinib Hydrochloride is the hydrochloride salt form of ponatinib, a potent multi-targeted kinase inhibitor. It effectively inhibits Abl, PDGFRα, VEGFR2, and other kinases at low nanomolar concentrations and is used in research for studying resistant cancers in both cellular and animal models.

Research Area

Cardiovascular Research, Cell Biology, Signal Transduction

Key Properties

• CAS Number: 1114544-31-8
• MW: 569.02
• Purity: >99.99% (May vary between batches)
• Formula: C₂₉H₂₈ClF₃N₆O
• SMILES: Cl.CN1CCN(Cc2ccc(NC(=O)c3ccc(C)c(c3)C#Cc3cnc4cccnn34)cc2C(F)(F)F)CC1
• Target: PDGFR,FGFR,VEGFR,Autophagy,Src,Bcr-Abl
• Solubility: DMSO:60 mg/mL (105.44 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.51 mM)

Bioactivity

• Target IC50:
  PDGFRα:1.1 nM|FGFR1:2.2 nM|Lyn:0.24 nM|Abl:0.37 nM|Src:5.4 nM|VEGFR2:1.5 nM

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

FGFR1, AP 24534, AP 24534 Hydrochloride, AP24534 Hydrochloride, AP-24534 Hydrochloride, VEGFR2, PDGFRα, Ponatinib hydrochloride, Src

Compound Identifiers

PubChem CID

46908927