Polyinosinic-polycytidylic acid sodium

SKU: orb1309224

Description

Poly(I:C) sodium salt is a synthetic double-stranded RNA analog that potently activates TLR3 and RIG-I/MDA5 pathways. It is widely used in research to model viral infection and stimulate innate immune responses in both in vitro cell cultures and in vivo animal studies.

Research Area

Cell Biology, Immunology & Inflammation

Key Properties

• CAS Number: 42424-50-0
• MW: 695.403
• Formula: (C₁₀H₁₃N₄O₈P)x.(C₉H₁₄N₃O₈P)x.xNa
• SMILES: [NaH].Nc1ccn([C@@H]2O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]2O)c(=O)n1.O[C@@H]1[C@@H](COP(O)(O)=O)O[C@H]([C@@H]1O)n1cnc2c1nc[nH]c2=O
• Target: TLR,Apoptosis
• Solubility: DMSO:< 1 mg/mL (insoluble or slightly soluble);H2O:90 mg/mL (129.42 mM)

Bioactivity

• In Vivo:
  Polyinosinic-polycytidylic acid significantly inhibits tumor growth in NOD/SCID immunodeficient mice injected with 1205Lu cells, resulting in a 50% reduction in human DNA levels in treated mice.
• In Vitro:
  Polyinosinic-polycytidylic acid (polyi:c) is a synthetic analog of double-stranded RNA and an agonist of toll-like receptor (TLR) 3 and retinoic acid inducible gene I (RIG-I)-like receptors (RLRs), including RIG-I and melanoma differentiation-associated gene 5 (MDA5). The effect of polyi:c on tumor immunotherapy has been well explored for several decades. The accumulated evidence suggests that polyi:c could be used as a vaccine adjuvant to enhance innate and adaptive immune responses, and to alter the tumor microenvironment. Recent studies have also shown that activation of TLR3 and RLR signaling by polyi:c can directly trigger apoptosis in some cancer cells.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

apoptosis, Apoptosis, annealing, double-stranded, dsRNA, Inhibitor, MDA5, inhibit, immunotherapy, microenvironment, Polyinosinic polycytidylic acid sodium, Polyinosinicpolycytidylic acid sodium, Polyinosinic-polycytidylic acid sodium, Polyinosinic-polycytidylic acid, Poly(I:C), Poly(I:C) sodium, Toll-like Receptor (TLR), proper, TLR, TLR3, tumor, RNA, RIG-I

Compound Identifiers

PubChem CID

168312302