Physostigmine Salicylate

SKU: orb1224614

Description

Physostigmine is a parasympathomimetic alkaloid, specifically, a reversible cholinesterase inhibitor. It occurs naturally in the Calabar bean.(In Vivo):Physostigmine salicylate (Eserine salicylate; 0.03-0.3 mg/kg; s.c.; daily for 6 weeks) improves deficits in contextual and cued memory in Tg(+) mice.Physostigmine salicylate (IV; 0.1, 0.2 mg/kg) delays time to emergence from isoflurane anesthesia at doses ≥0.2 mg/kg in male Sprague-Dawley rats.

Key Properties

• CAS Number: 57-64-7
• MW: 413.48
• Purity: >98% (HPLC)
• Formula: C₂₂H₂₇N₃O₅
• SMILES: C[C@@]12CCN([C@@H]1N(C3=C2C=C(C=C3)OC(=O)NC)C)C.C1=CC=C(C(=C1)C(=O)O)O
• Target: AChR
• Solubility: DMSO: 10 mM

Bioactivity

• In Vivo:
  Animal model: Heterozygous transgenic mice (Tg(+) mice). Dosage: 0.03, 0.1, and 0.3 mg/kg. Administration: SC; daily for 6 weeks. Result: Tended to normalize the contextual memory deficit in Tg(+) animals so that they became more similar to Tg(-) animals.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

AChR