Ozanimod

SKU: orb1300342

Description

Ozanimod (RPC-1063) is an orally administered, selective sphingosine-1-phosphate receptor 1 (S1PR1) modulator. It is widely used in preclinical and clinical research for immune-mediated conditions, including investigations into multiple sclerosis and inflammatory bowel diseases such as ulcerative colitis and Crohn's disease.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1306760-87-1
• MW: 404.46
• Purity: 99.74% (May vary between batches)
• Formula: C₂₃H₂₄N₄O₃
• SMILES: CC(C)Oc1ccc(cc1C#N)-c1nc(no1)-c1cccc2[C@H](CCc12)NCCO
• Target: S1P Receptor,LPL Receptor
• Solubility: Ethanol:10 mg/mL (24.72 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.94 mM);DMSO:41.67 mg/mL (103.03 mM);H2O:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

• Target IC50:
  S1P5 receptor:11 nM(EC50)|S1P1 receptor:0.41 nM(EC50)
• In Vivo:
  In vivo, Ozanimod shows high oral bioavailability and volume of distribution. In a MOG-induced EAE mouse model, Ozanimod (3 mg/kg, p.o.) suppresses Clinicalal symptoms. In a rat TNBS model of inflammatory bowel disease, Ozanimod (1.2 mg/kg, p.o.) inhibits Clinicalal and histological disease scores. In a Na ve CD4+CD45Rbhi T cell adoptive transfer model, Ozanimod (1.2 mg/kg, p.o.) also significantly reduced disease severity as assessed by measuring the degree of inflammation, gland loss, hyperplasia, neutrophil infiltrate and mucosal thickness.
• In Vitro:
  In S1P1R-HEK293T cells, Ozanimod induces sustained S1P1R internalization and degradation.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

neurosurgery, Ozanimod, Lysophospholipid Receptor, LPL Receptor, LPLReceptor, LPL, inhibit, multiple sclerosis (MS), Inhibitor, RPC1063, RPC-1063, RPC 1063, S1P1, S1PReceptor, S1P5, S1P receptor subtypes 1 (S1P1), S1P receptor subtypes 5 (S1P5), S1P Receptor, sphingosine 1-phosphate (S1P)

Compound Identifiers

PubChem CID

52938427