Nur77 agonist-1

SKU: orb3028178

Description

Nur77 agonist-1 (Compound 8f) is an orally active Nur77 agonist. It induces ferroptosis by upregulating Nur77 protein expression, increasing reactive oxygen species (ROS) and lipid peroxidation levels, while decreasing GPX4 protein expression. Nur77 agonist-1 binds with affinity to the ligand binding domain of Nur77, with a KD of 13.80 μM. It demonstrates significant antiproliferative activity against various breast cancer cells (IC50: 2.15-3.26 μM) and exhibits low cytotoxicity towards normal cells. This compound is useful for breast cancer research.

Research Area

Cell Biology, Immunology & Inflammation, Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 2899254-71-6
• MW: 443.885
• Formula: C₂₄H₁₈ClN₅O₂
• SMILES: O=C(NC1=CC=C(C=C1)C(=O)NN=CC=2C=CC=C(Cl)C2)NC3=CC=C4N=CC=CC4=C3
• Target: Reactive Oxygen Species,Glutathione Peroxidase,NR4A,Ferroptosis

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Reactive Oxygen Species,Glutathione Peroxidase,NR4A,Ferroptosis