Nelfinavir

SKU: orb1299514

Description

Nelfinavir (AG1341) is a potent HIV-1 protease inhibitor (Ki=2 nM) used in antiretroviral therapy. Research has also investigated its broad-spectrum anticancer properties in vitro, including the induction of endoplasmic reticulum stress and the inhibition of tumor cell proliferation in various cancer models.

Research Area

Infectious Disease & Virology, Protein Biochemistry

Key Properties

• CAS Number: 159989-64-7
• MW: 567.78
• Purity: 99.50%
• Formula: C₃₂H₄₅N₃O₄S
• SMILES: Cc1c(O)cccc1C(=O)N[C@@H](CSc1ccccc1)[C@H](O)CN1C[C@H]2CCCC[C@H]2C[C@H]1C(=O)NC(C)(C)C
• Target: HIV Protease
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (7.04 mM);DMSO:100 mg/mL (176.12 mM)

Bioactivity

• Target IC50:
  HIV:2 nM (ki)
• In Vitro:
  Nelfinavir decreased the viability of a panel of drug-resistant breast cancer cell lines and inhibited the growth of NSCLC xenografts that was associated with induction of ER stress, autophagy, and apoptosis. Nelfinavir is a lead HIV protease inhibitor with pleiotropic effects in cancer cells

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Human immunodeficiency virus, Inhibitor, HIV, HIV Protease, HIV-1, HIVProtease, myeloma, multiple, infection, inhibit, Nelfinavir, AG 1341, AG1341, AG-1341, cells, proliferation, protease, production, phosphorylation

Compound Identifiers

PubChem CID

64143