N6-Propargyl-ATP (N6pATP)

SKU: orb1734890

Description

N6-Propargyl-ATP (N6pATP)

Images & Validation

• Application Notes:
  in vitro AMPylation of proteins, in vitro polyadenylation of RNA. The resulting alkyne-functionalized protein or RNA can subsequently be processed via Cu(I)-catalyzed (azide-alkyne) click chemistry that offers the choice: to introduce a Biotin group for subsequent purification tasks (via Azides of Biotin); to introduce fluorescent group for subsequent microscopic imaging (via Azides of fluorescent dyes); to crosslink the RNA to azide-functionalized biomolecules e.g.proteins. Agonistic ligand, mainly for nucleoside receptor A1 Nucleoside-triphosphates can be converted by different membranebound phosphatases into nucleosides acting as nucleoside receptor ligands. In some cases nucleoside phosphates act also directly on nucleoside receptors. ; Spectroscopic Propertie: max 262 nm, 18.0 L mmol-1 cm-1 (Tris-HCl, pH 7.5).

Key Properties

• MW: Theoretical MW: 545.23 g/mol (free acid); Detected MW: 545.01 g/mol (free acid)
• Purity: 95% (HPLC)
• Formula: C₁₃H₁₈N₅O₁₃P₃
• SMILES: O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(=O)(OP(=O)(OP(=O)(O)O)O)O)n1c2c(c(ncn2)NCC#C)nc1
• Solubility: 10 mM Tris-HCl pH 7.5

Storage & Handling

• Storage: store at -20 °C. Short term exposure (up to 1 week cumulative) to ambient temperature possible
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

N6-Propargyl-adenosine-5'-triphosphate, Sodium salt