N6-(2-Phenylethyl)adenosine

SKU: orb1309362

Description

N6-(2-Phenylethyl)adenosine (N6-Phenethyladenosine) is a potent adenosine receptor agonist, exhibiting high affinity for the A1 receptor subtype. It is widely used in pharmacological research to study adenosine signaling in both in vitro binding assays and in vivo models of cardiac, neurological, and metabolic function.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 20125-39-7
• MW: 371.39
• Purity: 99.94%
• Formula: C₁₈H₂₁N₅O₄
• SMILES: OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(NCCc3ccccc3)ncnc12
• Target: Adenosine Receptor
• Solubility: H2O:< 0.1 mg/mL (insoluble);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (8.89 mM);DMSO:95 mg/mL (255.8 mM)

Bioactivity

• Target IC50:
  A1AR (human):30.1 nM (ki)|A1AR (rat):ki:11.8 nM |A3AR (human):0.63 nM (ki)
• In Vitro:
  The Ki value of human A3 is 0.63 nM. In CHO cells, N6-(2-Phenylethyl)adenosine inhibits A2 with IC50s of 560 nM and 2250 nM for rat and human.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, N6 (2 Phenylethyl)adenosine, N6-Phenethyladenosine, N6-Phenylethyladenosine, N6(2Phenylethyl)adenosine, N-6-(2-Phenylethyl)adenosine, N6-(2-Phenylethyl)adenosine, Inhibitor, derivative, A3AR, A2AR, A3, A1, A1AR, A2, AdenosineReceptor, adenosine, Adenosine Receptor, P1 receptor

Compound Identifiers

PubChem CID

9929340