N-Desmethyl Pimavanserin

SKU: orb1692415

Description

N-Desmethyl Pimavanserin (AC-279) is the primary active metabolite of the antipsychotic pimavanserin. As a 5-HT2A receptor inverse agonist, it is a valuable research tool for investigating serotonin receptor pharmacology in both in vitro and in vivo models related to neuropsychiatric and sleep disorders.

Research Area

Metabolism Research, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 639863-77-7
• MW: 413.53
• Purity: 98.44% (May vary between batches)
• Formula: C₂₄H₃₂FN₃O₂
• SMILES: CC(C)COc1ccc(CNC(=O)N(Cc2ccc(F)cc2)C2CCNCC2)cc1
• Target: 5-HT Receptor,Drug Metabolite
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.84 mM);DMSO:50 mg/mL (120.91 mM)

Bioactivity

• In Vitro:
  For Pimavanserin and its metabolite N-Desmethyl Pimavanserin (AC-279), the mean plasma half-lives are 57 hours and 200 hours, respectively.

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

5HTReceptor, 5HT Receptor, 5-HT2A, AC-279

Compound Identifiers

PubChem CID

25207724