Mouse IL-7 R alpha&TSLP R Heterodimer Protein, Fc Tag&Fc Tag

SKU: orb3158170

Description

TSLP is a pleiotropic cytokine originally characterized as a lymphocyte growth factor. Thymic stromal lymphopoietin (TSLP) is overexpressed in the airways of severe asthmatics and is an upstream cytokine that orchestrates inflammatory responses in asthma. Mouse TSLP exerts its biological activities by binding to a high-affinity heteromeric receptor complex composed of TSLPR and IL- 7 receptor and initiates signaling in cells co-expressing TSLPR and IL-7R.

Images & Validation

• Application Notes:
  Mouse IL-7 RA&TSLP R Heterodimer Protein, Fc Tag&Fc Tag is produced by co-expression of IL-7 RA and TSLP R, has a calculated MW of 51.5 kDa (IL-7 RA) & 48.8 kDa (TSLP R). Subunit IL-7 RA is fused with a human IgG1 Fc fragment at the C-terminus and subunit TSLP R is fused with a human IgG1 Fc fragment at the C-terminus. The protein migrates as 55-65 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

Key Properties

• Expression System: HEK293
• Target: IL-7 R alpha & TSLP R
• Reactivity: Mouse
• Tag: C-Fc | C-Fc
• Molecular Weight: 51.5 kDa (IL-7 RA) & 48.8 kDa (TSLP R)
• Expression Region: Glu 21 - Asp 239 (IL-7 RA) & Ala 20 - Pro 232 (TSLP R)
• Purity: 90%
• Endotoxins: 0.1 EU per μg
• Conjugation: Unconjugated

Storage & Handling

• Storage: -20°C
• Form/Appearance: Powder
• Buffer/Preservatives: PBS, pH 7.4
• Expiration Date: 6 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

IL-7 R alpha & TSLP R

RefSeq:P16872, Q8CII9