Mitochondrial fusion promoter M1

SKU: orb1218428

Description

Mitochondrial fusion promoter M1 is a mitochondrial dynamic modulator. Mitochondrial fusion promoter M1 preserves the mitochondrial function and promotes cellular respiration. Mitochondrial fusion promoter M1 alleviates cardiac and brain damage in rats with cardiac ischemia/reperfusion injury.

Key Properties

• CAS Number: 219315-22-7
• MW: 364.05
• Purity: >98% (HPLC)
• Formula: C₁₄H₁₀Cl₄N₂O
• SMILES: CC(c(cc(cc1)Cl)c1O)=NNc(c(Cl)cc(Cl)c1)c1Cl
• Target: Mitochondria
• Solubility: DMSO:46 mg/mL (126.35 mM; Need ultrasonic)

Bioactivity

• In Vivo:
  Animal model: Male Wistar rats (250-300g) receiving cardiac ischemia/reperfusion (I/R). Dosage: 2 mg/kg. Administration: I. v. 15 minutes before cardiac I/R injury. Result: Increased brain mitochondrial fusion. Increased blood-brain barrier (BBB) tight junction protein, and reduced macrophage in ltration in the brain. Reduced brain mitochondrial dysfunction and apoptosis, but it did not reduce mitochondrial oxidative stress. Reduced the expression of Alzheimer’s disease (AD)-related proteins.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Mitochondria