Minretumomab Antibody

SKU: orb1942972

Description

Minretumomab (CC-49) is a murine monoclonal antibody derived from B72.3 that specifically binds the TAG-72 tumor-associated antigen. It serves as a research tool for investigating carcinomas, including breast, colon, lung, and pancreatic cancers, in both in vitro and in vivo experimental models.

Research Area

Immunology & Inflammation

Key Properties

• CAS Number: 195189-17-4
• MW: ~150 kDa
• Purity: 95.00%
• Target: Mucin

Bioactivity

• In Vivo:
  Methods: In this study, subcutaneous, orthotopic, and peritoneal carcinomatosis mouse models were established using the colorectal cancer cell line LS174T. The humanized anti-TAG-72 antibody (Minretumomab) was conjugated with the near-infrared dye IR800CW and administered via tail vein injection. Fluorescence imaging was performed 72 hours after injection. Results: In the subcutaneous model, the optimal imaging was achieved with a 50 μg dose of Minretumomab, yielding a tumor-to-liver fluorescence ratio of 7.39. In the orthotopic model, metastatic lesions smaller than 1 mm were clearly detected by fluorescence imaging but were invisible under bright light, demonstrating the probe’s high sensitivity and specificity for tumor imaging.

Storage & Handling

• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CC-49

Quick Database Links

Gene Symbol

Mucin