LYN-1604 dihydrochloride

SKU: orb1298617

Description

LYN-1604 is a novel small molecule activator of ULK1. It induces cell death through mechanisms involving ATF3, RAD21, and caspase-3, concomitant with autophagy and apoptosis. This compound is a useful research tool for studying autophagy, cell death pathways, and oncology in both cellular and animal models.

Research Area

Cell Biology

Key Properties

• CAS Number: 2310109-38-5
• MW: 657.54
• Purity: 99.92%
• Formula: C₃₃H₄₅Cl₄N₃O₂
• SMILES: Cl.Cl.CC(C)CN(CC(C)C)CC(=O)N1CCN(CC(OCc2ccc3ccccc3c2)c2ccc(Cl)cc2Cl)CC1
• Target: Apoptosis,Autophagy
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.04 mM);DMSO:25 mg/mL (38.02 mM)

Bioactivity

• Target IC50:
  ULK1:18.94 nM (EC50)
• In Vitro:
  LYN-1604, to be the best candidate for a ULK1 agonist. LYN-1604 induced cell death involved in ATF3, RAD21, and caspase3, accompanied by autophagy and apoptosis. LYN-1604 has potential for good therapeutic effects on TNBC by targeting ULK1-modulated cell death in vivo

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, LYN 1604, LYN 1604 Dihydrochloride, LYN 1604 dihydrochloride, LYN1604, LYN-1604, LYN-1604 2HCl, LYN1604 Dihydrochloride, LYN1604 dihydrochloride, LYN-1604 Dihydrochloride, LYN-1604 2HCl(2216753-86-3 free base), negative, Inhibitor, activator, 2216753-86-3, 2216753-86-3 free base, cancer, Apoptosis, anti-tumor, Autophagy, breast, TNBC, triple, Unc-51 like kinase, ULK, ULK1

Compound Identifiers

PubChem CID

131954512