LY88074

SKU: orb1709216

Description

LY88074 is a raloxifene derivative lacking the basic side chain, which acts as an ERβ agonist with an EC50 of 232 nM. This compound has been shown to promote uterine cell proliferation in research models, making it a useful tool for studying estrogen receptor subtype-specific functions in vitro and in vivo.

Research Area

Metabolism Research

Key Properties

• CAS Number: 177744-96-6
• MW: 362.4
• Purity: 98.31% (May vary between batches)
• Formula: C₂₁H₁₄O₄S
• SMILES: C(=O)(C1=C(SC=2C1=CC=C(O)C2)C3=CC=C(O)C=C3)C4=CC=C(O)C=C4
• Target: Estrogen Receptor/ERR,Others,Estrogen/progestogen Receptor
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.76 mM);DMSO:3.63 mg/mL (10.02 mM)

Bioactivity

• Target IC50:
  ERβ:232 nM(EC50)
• In Vitro:
  The interaction of LY88074 with collagen matrix, although significant, is less than the interaction found with Raloxifene.Removal of the aminoethylpiperdine moiety, as in LY88074, reduces bone binding, compared to Raloxifene.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

LY88074, LY-88074, LY 88074, ERβ, Estrogen Receptor, EstrogenReceptor, progestogen Receptor, progestogenReceptor

Compound Identifiers

PubChem CID

9863785