LY377604

SKU: orb1707032

Description

LY377604 is a selective β3-adrenergic receptor agonist (EC50 = 2.4 nM) with antagonistic activity at β1/β2 receptors. This pharmacological profile makes it a useful research compound for investigating metabolic diseases, such as obesity, in both cellular and animal models.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 204592-94-9
• MW: 524.61
• Purity: >99.99% (May vary between batches)
• Formula: C₃₁H₃₂N₄O₄
• SMILES: O(C[C@H](CNC(CC1=CC=C(OC2=CC=C(C(N)=O)C=N2)C=C1)(C)C)O)C3=C4C=5C(NC4=CC=C3)=CC=CC5
• Target: Adrenergic Receptor
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (6.29 mM);DMSO:80 mg/mL (152.49 mM)

Bioactivity

• Target IC50:
  β3-adrenoceptor (human):2.4 nM (EC50)
• In Vivo:
  LY377604 administered orally at 10mg/kg increases diet-induced obesity in male Long-Evans rats by enhancing calorie expenditure.
• In Vitro:
  LY377604 is a β1- and β2-adrenergic receptor antagonist as well as a β3-adrenergic receptor agonist, causing a maximal increase in cyclic adenosine monophosphate (cAMP) levels with an EC50 of 2.4 nM.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

β1-adrenergic receptor, β2-adrenergic receptor, β1-adrenergic receptor, β2-adrenergic receptor, β3-adrenergic receptor, LY 377604, LY377604, LY-377604, human β3-adrenergic receptor, AdrenergicReceptor, Adrenergic Receptor

Compound Identifiers

PubChem CID

9849699