Ligustilide

SKU: orb1301294

Description

Ligustilide

Research Area

Cell Biology

Key Properties

• CAS Number: 4431-01-0
• MW: 190.24
• Purity: 98.14%
• Formula: C₁₂H₁₄O₂
• SMILES: CCC1(C)C2OC(=O)C3C=CCCC123
• Target: Autophagy,Apoptosis
• Solubility: DMSO:1.91 mg/mL (10.04 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (5.26 mM)

Bioactivity

• In Vitro:
  To investigate the neuroprotective of ligustilide (LIG) against glutamate-induced apoptosis of PC12 cells, cell viability were examined by MTT assay. Pretreatment with ligustilide (1, 5, 15 μmol · L(-1)) significantly improved cell viability. The apoptosis rate in glutamate-induced PC12 cells was 13.39%, and decreased in the presence of ligustilide (1, 5, 15 μmol · L(-1)) by 9.06%, 6.48%, 3.82%, separately. Extracellular accumulation of Ca2+ induced by glutamate were significantly reduced by ligustilide .

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, inhibit, Ligustilide, Apoptosis, Autophagy

Compound Identifiers

PubChem CID

158018