L-Lactic acid

SKU: orb1302516

Description

L-Lactic acid, the (S)-enantiomer of 2-hydroxypropanoic acid, is a key metabolite generated from pyruvate during anaerobic glycolysis. It serves as a critical biomarker for tissue hypoxia and hemodynamic status in critical care research, with applications in studying cellular metabolism, ischemia-reperfusion injury, and metabolic phenotyping in both in vitro and in vivo models.

Research Area

Infectious Disease & Virology, Metabolism Research

Key Properties

• CAS Number: 79-33-4
• MW: 90.08
• Purity: 99.85% (May vary between batches)
• Formula: C₃H₆O₃
• SMILES: [C@@H](C(O)=O)(C)O
• Target: Endogenous Metabolite,Antibacterial,Antibiotic
• Solubility: 10% DMSO+90% Saline:5 mg/mL (55.51 mM);5% DMSO+95% Saline:2.63 mg/mL (29.2 mM);DMSO:262 mg/mL (2908.53 mM);Saline:50 mg/mL (555.06 mM)

Bioactivity

• Target IC50:
  LDHA:3 nM
• In Vivo:
  METHODS: To study its effect on swimming endurance, L-Lactic acid (25-50 mg/kg in 0.9% NaCl) was administered intraperitoneally to ICR mice. RESULTS: L-Lactic acid enhanced the swimming endurance of mice, and the effect was dose-dependent. METHODS: To investigate the effect on endotoxemia, L-Lactic acid (80 mg/kg) was intraperitoneally injected into mice, and 20 h later, a lethal dose of LPS (25 mg/kg) was intraperitoneally injected into mice to induce infectious shock. RESULTS: L-Lactic acid significantly inhibited LPS-induced cytokine induction in mice following endotoxemia.L-Lactic acid treatment decreased glucose uptake and lactate output during LPS stimulation.
• In Vitro:
  METHODS: Mouse CD4+CD25-T cells were treated with low-glucose medium containing L-Lactic acid (5-20 mM), and Teff proliferation was detected by Flow cytometry. RESULTS: L-Lactic acid had a sustained inhibitory effect on T cell proliferation, and apoptosis-independent effect. METHODS: T cells were cultured in medium containing L-Lactic acid (20 mM), and ROS levels were measured using ROS and superoxide detection assay kits. RESULTS: A significant reduction in ROS and O2- production was observed in L-Lactic acid-treated T cells.

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

EndogenousMetabolite, Endogenous Metabolite, L-(+)-Lactic acid, L Lactic acid, Inhibitor, LLactic acid, L-Lactic acid, inhibit, Antibiotic, Bacterial, 2-Hydroxypropanoic acid, 2-HYDROXYPROPIONIC ACID, (S)-2-Hydroxypropanoic acid

Compound Identifiers

PubChem CID

107689