L-Glutathione reduced

SKU: orb1309822

Description

L-Glutathione reduced is an endogenous tripeptide and a major cellular antioxidant that scavenges free radicals. It serves as a cofactor for enzymes, aids in protein disulfide bond rearrangement, and reduces peroxides. This molecule is widely used in research on oxidative stress, cell signaling, and detoxification pathways in both in vitro and in vivo models.

Research Area

Cell Biology, Immunology & Inflammation, Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 70-18-8
• MW: 307.32
• Purity: 99.99% (May vary between batches)
• Formula: C₁₀H₁₇N₃O₆S
• SMILES: NC(CCC(=O)NC(CS)C(=O)NCC(O)=O)C(O)=O
• Target: Endogenous Metabolite,Glutathione reductase,ROS,Reactive Oxygen Species,Ferroptosis
• Solubility: H2O:153.7 mg/mL (500.13 mM);DMSO:Insoluble

Bioactivity

• Target IC50:
  KB-V1 cells:> 20 mM|Glyoxalase I:18 mM (Ki)|KB 3-1 cells:> 20 mM
• In Vivo:
  METHODS: To study in vivo activity, L-Glutathione reduced (100 mg/kg) was administered orally to mice and GSH concentrations were measured in plasma at 30, 45, and 60 min, and in the liver, kidneys, heart, lungs, brain, small intestine, and skin 1 h later. RESULTS: Within 30 min of oral L-Glutathione reduced administration, plasma GSH concentrations increased from 30 µM to 75 µM, consistent with a rapid flow of GSH from the intestinal lumen to the plasma. Under these conditions of GSH sufficiency, GSH concentrations in most tissues did not exceed control values over the same time course, with the exception of lung.
• In Vitro:
  METHODS: NSCs cells were treated with L-Glutathione reduced (0.5 mM) and sevoflurane (3%) for 24 h. Apoptosis was detected using TUNEL staining. RESULTS: Supplementation with reduced L-Glutathione reduced the effect of sevoflurane on apoptosis of NSCs.

Storage & Handling

• Storage: keep away from direct sunlight | Powder: -20°C for 3 years | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

L Glutathione reduced, Isethion, LGlutathione reduced, L-Glutathione reduced, Ferroptosis, Endogenous Metabolite, EndogenousMetabolite, gamma-L-Glutamyl-L-cysteinyl-glycine, GSH, Glutathionereductase, Glutathione reductase, Glutathion, Glutathione, Tathion, r-L-Glutamyl-L-cysteinyl-glycine, Reactive Oxygen Species, ReactiveOxygenSpecies, γ-L-Glutamyl-L-cysteinyl-glycine

Compound Identifiers

PubChem CID

745