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JP-11646

SKU: orb2279720

Description

JP-11646 is a novel potent, selective, non-ATP competitive Pim2 inhibitor with IC50 of 0.5/1/24 nM for Pim2/3/1, respectively; shows less potency for other kinases in a kinase selectivity panel; exhibits 4-760-fold greater suppression of MM proliferation and viability than ATP-competitive PIM inhibitors; significant reduces tumor burden and increases median survival in xenogeneic myeloma murine models.

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Key Properties

CAS Number1902983-63-4
Purity0.98

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DisclaimerFor research use only
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JP-11646 (orb2279720)

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10 mg
$ 950.00
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