JP-11646

SKU: orb2279720

Description

JP-11646 is a novel potent, selective, non-ATP competitive Pim2 inhibitor with IC50 of 0.5/1/24 nM for Pim2/3/1, respectively; shows less potency for other kinases in a kinase selectivity panel; exhibits 4-760-fold greater suppression of MM proliferation and viability than ATP-competitive PIM inhibitors; significant reduces tumor burden and increases median survival in xenogeneic myeloma murine models.

Key Properties

• CAS Number: 1902983-63-4
• Purity: 0.98

Storage & Handling

• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only