Isotretinoin

SKU: orb1308025

Description

Isotretinoin (13-cis-Retinoic acid) is a natural retinoic acid that activates nuclear RARs to modulate gene expression, promoting cellular differentiation and apoptosis. It is widely used in oncology, dermatology, and immunology research, demonstrating antineoplastic, anti-inflammatory, and keratinization-inhibiting effects in both in vitro and in vivo studies.

Research Area

Cell Biology, Metabolism Research

Key Properties

• CAS Number: 4759-48-2
• MW: 300.44
• Purity: 99.61% (May vary between batches)
• Formula: C₂₀H₂₈O₂
• SMILES: C(=C/C(=C/C=C/C(=C\C(O)=O)/C)/C)\C=1C(C)(C)CCCC1C
• Target: Endogenous Metabolite,Autophagy,Retinoid Receptor
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.66 mM);Ethanol:1 mg/mL (3.33 mM);DMSO:250 mg/mL (832.11 mM)

Bioactivity

• In Vivo:
  Isotretinoin (500 ng/mL) and its main metabolite in the human, 4-oxo-isotretinoin, induce malformations similar to those seen in vivo. Isotretinoin impairs explicit memory in Stage 2, but retention tests one month after Isotretinoin exposure ended, indicated recovery from this explicit memory impairment and evidence of enhanced implicit memory in the 10 mg and 15 mg ISO rats. Isotretinoin slows the recovery of rod signaling after exposure to an intense bleaching light, and that rhodopsin regeneration is markedly slowed. Isotretinoin is also found to protect rat photoreceptors from light-induced damage. Isotretinoin blocks the formation of A2E biochemically and the accumulation of lipofuscin pigments by electron microscopy. Isotretinoin also blocks the slower, age-dependent accumulation of lipofuscin in wild-type mice.
• In Vitro:
  Isotretinoin directly interferes with the development of cranial neural crest cells. Isotretinoin selectively affects neural crest cells by decreasing their cell-substratum adhesion.

Storage & Handling

• Storage: Powder: -20°C for 3 years | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

13-cis-Retinoic acid, anticancer, Autophagy, Inhibitor, EndogenousMetabolite, Endogenous Metabolite, orally active, Isotretinoin, inhibit, severe acne, RAR/RXR, RAR, Retinoic acid receptors, Retinoid Receptor, Retinoid X receptors, RetinoidReceptor, vitamin A

Compound Identifiers

PubChem CID

5282379