Isoguvacine hydrochloride

SKU: orb1309536

Description

Isoguvacine hydrochloride is a selective GABA receptor agonist that activates various αβγ and ρ1 subunit-containing GABAA receptors. It is widely used in neuroscience research for in vitro electrophysiology and binding studies to investigate GABAergic neurotransmission, receptor subtypes, and inhibitory signaling pathways.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 68547-97-7
• MW: 163.6
• Purity: 99.59% (May vary between batches)
• Formula: C₆H₁₀ClNO₂
• SMILES: Cl.OC(=O)C1=CCNCC1
• Target: GABA Receptor
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (12.22 mM);H2O:90 mg/mL (550.12 mM);DMSO:20 mg/mL (122.25 mM)

Bioactivity

• In Vitro:
  Treatment of 50 μM Isoguvacine to block epileptiform events in 2 of 6 organotypic hippocampal slice cultures, Isoguvacine dose-dependently inhibits hypomagnesium-induced epileptiform events. Isoguvacine binds to mouse forebrain synaptic membrane preparations and can specifically bind to GABA, muscimol and bicuculline, but not picrotoxin or diaminobutyric acid. The highest levels of binding are observed in the cerebellum, cortex and hippocampus.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

γ-Aminobutyric acid Receptor, 1,2,3,6-tetrahydro-4-pyridinecarboxylic acid hydrochloride, GABAReceptor, GABA, GABA Receptor, Gamma-aminobutyric acid Receptor, Inhibitor, Isoguvacine, Isoguvacine Hydrochloride, Isoguvacine hydrochloride, inhibit

Compound Identifiers

PubChem CID

155107