Ifenprodil Tartrate

SKU: orb1309475

Description

Ifenprodil is a selective antagonist of NMDA receptors, specifically targeting those containing the GluN2B subunit. It is widely used in neuroscience research to study glutamate signaling, neuroprotection, and excitotoxicity in both cellular and animal models of neurological disorders.

Research Area

Infectious Disease & Virology, Metabolism Research, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 23210-58-4
• MW: 400.49
• Purity: 99.70%
• Formula: C₂₁H₂₇NO₂·1/2C₄H₆O₆
• SMILES: O[C@H]([C@@H](O)C(O)=O)C(O)=O.CC(C(O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1.CC(C(O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1
• Target: Influenza Virus,NMDAR,Adrenergic Receptor,iGluR,Calcium Channel,Potassium Channel
• Solubility: 10% DMSO+90% Saline:2 mg/mL (4.99 mM);H2O:9 mg/mL (22.47 mM);DMSO:45 mg/mL (112.36 mM);Ethanol:58 mg/mL (144.82 mM)

Bioactivity

• Target IC50:
  NMDAR:0.3 μM
• In Vivo:
  Ifenprodil inhibits NMDA-induced currents at both 10 μM and 100 μM, with IC50 values of 0.88 μM and 0.17 μM, respectively. In rat cortical neurons, Ifenprodil (10 μM) suppresses the majority of currents elicited by NMDA receptors.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

NR1A, NR2B, KcsA, inhibit, Ionotropic glutamate receptors, NMDA receptor, NMDA, iGluR, Ifenprodil, Ifenprodil Tartrate, Inhibitor, cerebral, current, PotassiumChannel, Potassium Channel, vasodilator

Compound Identifiers

PubChem CID

656586