HYPOCRELLIN B

SKU: orb1301497

Description

Hypocrellin B is a natural photosensitive pigment derived from Hypocrella bambusae. It acts as a photosensitizer in photodynamic therapy research, inducing apoptosis in cancer cells like ovarian carcinoma and exhibiting antibacterial activity against Staphylococcus through ROS generation and cell wall damage.

Research Area

Cell Biology, Infectious Disease & Virology

Key Properties

• CAS Number: 123940-54-5
• MW: 528.51
• Purity: 98.87% (May vary between batches)
• Formula: C₃₀H₂₄O₉
• SMILES: COc1c(O)c2c3c(O)cc(OC)c4c(OC)cc5C(=O)C(=O)C(OC)=C6CC(C)=c(c1C(C)=O)c2c6c5c34
• Target: Parasite,Antifungal,Apoptosis
• Solubility: DMSO:Slightly soluble

Bioactivity

• In Vitro:
  Photodynamic therapy with hypocrellin B remarkably induced apoptosis and inhibited adhesion and migration of cancer cells in vitro.
• Cell Research:
  Human ovarian cancer HO-8910 cell as a cancer model cell was incubated with hypocrellin B at a concentration of 2.5 μM for 5 h and irradiated by light from a light-emitting diodes (LED) source. Cell apoptosis was analyzed by flow cytometry with annexin V/propidium iodide (PI) staining and nuclear staining 6 h after hypocrellin B photoirradiation. Cell adhesion was assessed using the 3-(4, 5-dimthylthiazol-2-yl)-2, 5 diphenyl-tetrazolium bromide (MTT) assay 4 h after photodynamic treatment. Cell migration was measured 48 h after photodynamic treatment.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, Mycobacterium intracellulare, Parasite, Hypocrellin, HYPOCRELLIN B, Inhibitor, Fungal, antileishmanial, Antimicrobial, Apoptosis, Apoptosis inducer, S. aureus, Staphylococcus aureus, Pseudomonas aeruginosa

Compound Identifiers

PubChem CID

130074