Hypaconitine

SKU: orb1300247

Description

Hypaconitine is a highly toxic diterpenoid alkaloid isolated from Aconitum plants. It exhibits notable anti-inflammatory properties, making it a compound of interest for researching rheumatism treatments. Its mechanisms are studied in both in vitro assays and in vivo models of inflammation.

Research Area

Cell Biology, Metabolism Research, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 6900-87-4
• MW: 615.71
• Purity: 99.63% (May vary between batches)
• Formula: C₃₃H₄₅NO₁₀
• SMILES: COCC12CCC(OC)C34C5CC6(O)C(OC(=O)c7ccccc7)C5C(OC(C)=O)(C(C(OC)C13)C4N(C)C2)C(O)C6OC
• Target: Cytochromes P450,Potassium Channel,TNF,Calcium Channel,NF-κB
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.25 mM);DMSO:50 mg/mL (81.21 mM)

Bioactivity

• In Vitro:
  Hypaconitine (0.08-2 microM) depressed the nerve-evoked twitch tension, without affecting the contraction evoked by stimulation of the muscle,At the concentrations of hypaconitine (up to 5 microM)that depressed the nerve-evoked twitch tension, the resting membrane potential of the muscle cells was unchanged. Hypaconitine (0.1-2 microM) blocked the end-plate potential (epp), without affecting the amplitude of the miniature epp (mepp). The quantal content of end-plate potentials was decreased by these agents in parallel with the decrement in amplitude.
• Animal Research:
  Adult Wistar rats were orally administered Hypaconitine (0.23, 0.69, 2.07 mg/kg per day), liquiritin (20 mg/kg per day), or Hypaconitine (2.07 mg/kg per day) plus liquiritin (20 mg/kg per day) for seven consecutive days. The mRNA expression levels of CaM and Cx43 in rat myocardial tissue were determined by real-time quantitative PCR. The protein contents of CaM and phosphorylated Cx43 (Ser368) were determined by Western blot

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CYP17, Hypaconitine, inhibit, Inhibitor, TNF Receptor, TNFR, Tumor Necrosis Factor Receptor

Compound Identifiers

PubChem CID

4526188