Homovanillyl alcohol

SKU: orb1297337

Description

Homovanillyl alcohol, a bioactive metabolite of the olive and wine phenolic hydroxytyrosol, exhibits potent antioxidant and dose-dependent anti-hemolytic activity. Research applications include investigating its cardioprotective mechanisms and potential role in reducing mortality through in vitro and in vivo studies on oxidative stress and cardiovascular disease models.

Research Area

Cell Biology, Metabolism Research

Key Properties

• CAS Number: 2380-78-1
• MW: 168.19
• Purity: 99.74%
• Formula: C₉H₁₂O₃
• SMILES: COC1=C(O)C=CC(CCO)=C1
• Target: TNF,Drug Metabolite
• Solubility: DMSO:125 mg/mL (743.21 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (11.89 mM)

Bioactivity

• In Vitro:
  Structurally related compounds have been assayed for their ability to reduce homocysteine-induced monocyte adhesion as well as the cell surface expression of intercellular adhesion molecule-1 (ICAM-1) in EA.hy.926 cells. As well-known, among the selected phenolic compounds, hydroxytyrosol, Homovanillyl alcohol, and the hydroxycinnamic acid derivatives caffeic and ferulic acid display high scavenging activities, while tyrosol and p-coumaric acid are poorly active. All of the tested compounds, approaching potential in vivo concentrations, significantly reduce homocysteine-induced cell adhesion and ICAM-1 expression.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

TNF-α, DrugMetabolite, Drug Metabolite, Inhibitor, Homovanillyl alcohol, inhibit

Compound Identifiers

PubChem CID

16928