Hexestrol

SKU: orb1300685

Description

Hexestrol is a potent synthetic estrogen receptor agonist, exhibiting high affinity for both ERα (EC50 = 0.07 nM) and ERβ (EC50 = 0.175 nM). It is widely used as a research tool in vitro and in vivo to study estrogen signaling, endocrine disruption, and hormone-responsive cancers.

Research Area

Metabolism Research

Key Properties

• CAS Number: 84-16-2
• MW: 270.37
• Purity: >99.99% (May vary between batches)
• Formula: C₁₈H₂₂O₂
• SMILES: [C@H]([C@H](CC)C1=CC=C(O)C=C1)(CC)C2=CC=C(O)C=C2
• Target: Estrogen/progestogen Receptor,Estrogen Receptor/ERR
• Solubility: H2O:< 1 mg/mL (insoluble or slightly soluble);Ethanol:39 mg/mL (144.25 mM);DMSO:50 mg/mL (184.93 mM)

Bioactivity

• Target IC50:
  ERβ:0.175 nM(EC50)|ERα:0.07 nM(EC50)
• In Vivo:
  Hexestrol administered intraperitoneally at dose of 6 mg/kg may decrease ovulation in mice, as evident by smaller ovaries and decreased luteal bodies and oocytes.
• In Vitro:
  Hexestrol binds to ERα with EC50 of 0.07 nM and to ERβ with EC50 of 0.175 nM. Hexestrol inhibits activity of AKR1B13 with IC50 of 3.2 μM. Hexestrol inhibits the d-galactose dehydrogenase activity of thermophilus aldose 1-dehydrogenase with IC50 of 0.063 mM. Hexestrol inhibits the dehydrogenase activity of AKR1C20 towards 10 μM 4-androsten-3α-o1-17-one with IC50 values of 2.7 μM. Hexestrol inhibits 17HSD5 with IC50 of 30 μM, and inhibits TBER1 with IC50 of 0.8 μM. Hexestrol reacts with DNA through the catechol quinone, thus can be a carcinogen.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Hexanoestrol, Hexestrofen, Hexestrol, ERR, ERβ, ERα, EstrogenReceptor, Estrogen Receptor/ERR, Estrogen Receptor, meso-Hexestrol, nonsteroidal, progestogen Receptor, progestogenReceptor

Compound Identifiers

PubChem CID

192197