Guanabenz Acetate

SKU: orb1300695

Description

Guanabenz acetate is a selective α2-adrenergic receptor agonist with pEC50 values of 8.25, 7.01, and ~5 for the α2A, α2B, and α2C subtypes, respectively. It is widely used in research to study receptor pharmacology, sympathetic nervous system function, and related physiological mechanisms in both cellular and animal models.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 23256-50-0
• MW: 291.13
• Purity: 99.83% (May vary between batches)
• Formula: C₈H₈Cl₂N₄·C₂H₄O₂
• SMILES: c1(c(cccc1Cl)Cl)/C=N/NC(=N)N.C(=O)(C)O
• Target: Adrenergic Receptor
• Solubility: DMSO:40 mg/mL (137.4 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.87 mM)

Bioactivity

• Target IC50:
  α2B-adrenoceptor:7.01(pEC50)|α2C-adrenoceptor:<5(pEC50)|α2A-adrenoceptor:8.25(pEC50)
• In Vivo:
  In mammalian MovS6 cells, 10 μM of Guanabenz facilitates the complete clearance of PrPSc. Additionally, in HEK293 cells transfected with rat inducible nitric oxide synthase (nNOS), 30 μM Guanabenz induces a time-dependent reduction in nNOS activity, with a Ki value of 1 μM. In HEK 293 cells, treatment with 50 μM Guanabenz for 3 hours results in approximately a 75% decrease in the accumulation of nitrites and nitrates within the cells. Furthermore, treatment with 100 μM Guanabenz for 24 hours leads to about a 35% reduction in the quantity of inducible nitric oxide synthase protein detected by immunological methods.
• In Vitro:
  Guanabenz inhibits the response of vascular contractions in various processes and initiates normal sympathetic nerve discharge, while also antagonizing the stimulation of the sympathetic nervous system. Administering 0.5 mg/kg of Guanabenz intravenously in anesthetized hypertensive rats and dogs leads to a reduction in blood pressure and heart rate. Moreover, an intravenous injection of 0.1 mg/kg Guanabenz in anesthetized dogs initially causes an increase in blood pressure due to the action of the sympathetic nervous system, followed by a decrease in cardiac output, contractility, and heart rate.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Beta Receptor, BR 750, BR750, BR-750, AdrenergicReceptor, Adrenergic Receptor, Guanabenz Acetate, Guanabenz, Inhibitor, inhibit, Wy 8678, Wy8678, Wy-8678, Wy8678 acetate, Wytensin, Wy8678 Acetate, α2B-adrenergic receptor, α2C-adrenergic receptor, α2A-adrenergic receptor

Compound Identifiers

PubChem CID

5702062