GTS-21 dihydrochloride

SKU: orb1305200

Description

GTS-21 dihydrochloride (DMBX-anabaseine) is a selective agonist for neuronal nicotinic acetylcholine receptors (nAChRs). It is widely used in neuroscience research to study cognitive function, neuroprotection, and receptor pharmacology in both in vitro and in vivo experimental models.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 156223-05-1
• MW: 381.3
• Purity: 99.62%
• Formula: C₁₉H₂₀N₂O₂·2HCl
• SMILES: COc1ccc(\C=C2/CCCN=C2c2cccnc2)c(OC)c1
• Target: 5-HT Receptor,AChR
• Solubility: DMSO:15 mg/mL (39.34 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.25 mM)

Bioactivity

• Target IC50:
  α4β2 (human):20 nM (Ki)|5-HT3A receptor:3.1 μM (IC50)

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

DMXB-A, DMBX-anabaseine, cognition, 5HT Receptor, 5HTReceptor, 5-hydroxytryptamine Receptor, 5-HT Receptor, anti?inflammatory, nAChR, Nicotinic acetylcholine receptors, lung, inhibit, Inhibitor, injury, GTS 21, GTS 21 dihydrochloride, GTS 21 Dihydrochloride, GTS21, GTS-21, GTS21 dihydrochloride, GTS21 Dihydrochloride, GTS-21 Dihydrochloride, fibrosis, Serotonin Receptor, pulmonary, α4β2 nAChR

Compound Identifiers

PubChem CID

5310985