Gramine

SKU: orb1300698

Description

Gramine (Donaxine) is a natural indole alkaloid that functions as an adiponectin receptor (AdipoR) agonist and a β2-adrenergic receptor (β2-AR) agonist. It exhibits anti-tumor, anti-viral, and anti-inflammatory activities, making it a useful research tool for metabolic, oncological, and immunological studies in both cellular and animal models.

Research Area

Infectious Disease & Virology, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 87-52-5
• MW: 174.24
• Purity: 99.95% (May vary between batches)
• Formula: C₁₁H₁₄N₂
• SMILES: CN(C)CC1=CNC2=C1C=CC=C2
• Target: Reverse Transcriptase,Adiponectin Receptor,Adrenergic Receptor
• Solubility: 2% DMSO+30% PEG300+5% Tween 80+63% Saline:2.4 mg/mL (13.77 mM);H2O:< 1 mg/mL (insoluble or slightly soluble);Ethanol:33 mg/mL (189.39 mM);DMSO:120 mg/mL (688.71 mM)

Bioactivity

• Target IC50:
  AdipoR2:3.2 μM|AdipoR1:4.2 μM

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ReverseTranscriptase, Reverse Transcriptase, Gramine, Inhibitor, NSC16892, NSC-16892, inhibit, NSC 16892, AdrenergicReceptor, Adrenergic Receptor, Adiponectinreceptor, AdipoRs, Adiponectin Receptor, Adiponectin receptor, Donaxine, Beta Receptor

Compound Identifiers

PubChem CID

6890