GR 46611

SKU: orb1305807

Description

GR 46611 is a selective agonist for the 5-HT1B and 5-HT1D receptors. This compound is utilized in neuroscience research, particularly in studies investigating the pathophysiology and potential treatment of epilepsy, employing both in vitro and in vivo experimental models.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 185259-85-2
• MW: 377.48
• Purity: 99.90% (May vary between batches)
• Formula: C₂₃H₂₇N₃O₂
• SMILES: COc1ccc(CNC(=O)\C=C\c2ccc3[nH]cc(CCN(C)C)c3c2)cc1
• Target: 5-HT Receptor
• Solubility: DMSO:11.3 mg/mL (29.94 mM);Ethanol:10 mM

Bioactivity

• In Vivo:
  GR 46611 (0.6 and 6 nmol; paraventricular hypothalamic nucleus (PVN)) promptly and reliably elicited feeding at their higher doses, without affecting drinking or non-ingestive behaviors. GR 46611 (6 nmol) elicited intense feeding responses in the n. medialis hypothalami posterioris and in the adjacent n. lateralis hypothalami posterioris (PMH/PLH complex, in the caudoventral hypothalamus) and in the n. magnocellularis preopticus (PPM, in the caudal preoptic region). GR 46611 (1 mg/kg) significantly increased the threshold of hyperthermia-induced seizure and lowered seizure severity thereby improving the survival of DS mice.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

5-HT1B, 5-HT1D, 5HT Receptor, 5HTReceptor, GR 46611, GR46611, GR-46611, Semaglutide Acetate(910463-68-2 Free base), Semaglutide Acetate(910463-68-2 Free base)

Compound Identifiers

PubChem CID

6160690