Gaboxadol (hydrochloride)

SKU: orb2655501

Description

Gaboxadol (hydrochloride) is a GABAA receptor agonist.(In Vitro):Gaboxadol hydrochloride (0.34, 3.5 and 7.0 μM) decreses permeability across Caco-2 cell monolayers with a dose dependent manner, shows the mean Papp values with 8.1 × 10-6 cm·s-1, 6.1 × 10-1 cm·s-6 and 5.6 × 10-6 cm·s-1 for 0.34, 3.5 and 7 μM gaboxadol, respectively.(In Vivo):Gaboxadol hydrochloride (intraperitoneal injection; 0.5, 1, 1.5, 2, 3, 4, or 5 mg/kg; once daily; three-day interval) normalizes the distance traveled by Fmr1 KO2 mice to WT activity levels at 0.5 mg/kg, additionally, this compound has no effect on locomotor activity in Fmr1 KO2 mice.

Key Properties

• CAS Number: 85118-33-8
• MW: 176.6
• Purity: >98% (HPLC)
• Formula: C₆H₉ClN₂O₂
• SMILES: Cl.O=c1[nH]oc2c1CCNC2
• Target: GABA
• Solubility: DMSO:75 mg/mL (424.69 mM)

Bioactivity

• In Vivo:
  Gaboxadol hydrochloride (intraperitoneal injection; 0.5, 1, 1.5, 2, 3, 4, or 5 mg/kg; once daily; three-day interval) normalizes the distance traveled by Fmr1 KO2 mice to WT activity levels at 0.5 mg/kg, additionally, this compound has no effect on locomotor activity in Fmr1 KO2 mice. Animal model: Fmr1 KO2 mice (deletion of the promoter and first exon of Fmr1 resulting in mRNA and protein null mice). Dosage: 0.5, 1, 1.5, 2, 3, 4, or 5 mg/kg. Administration: Intraperitoneal injection. Result: Normalized Hyperactivity Observed in Fmr1 KO2 mice.
• In Vitro:
  Gaboxadol hydrochloride (0.34, 3.5 and 7.0 μM) decreses permeability across Caco-2 cell monolayers with a dose dependent manner, shows the mean Papp values with8.1 x 10-6 cm·s-1, 6.1 x 10-1 cm·s-6 and 5.6 x 10-6 cm·s-1 for 0.34, 3.5 and 7 μM gaboxadol, respectively.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Lu 02-030 (hydrochloride) | THIP (hydrochloride)

Quick Database Links

Gene Symbol

GABA