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FXR agonist 3

SKU: orb1982428

Description

FXR agonist 3 is a potent small molecule that activates the Farnesoid X Receptor (FXR), demonstrating anti-NASH, antifibrotic, and hepatoprotective effects. It inhibits key fibrotic markers like COL1A1 (IC50 = 8.19 µM) in vitro and ameliorates liver injury in CDAHFD and BDL rodent models in vivo.

Research Area

Metabolism Research

Images & Validation

Key Properties

TargetOthers,FXR
Molecular Weight521.12
Purity95.04%
FormulaC28H28BrNO4
SMILESCOC1=CC2=C(C=C1OC)CC[N+]3=C2C=C4C(C(OCC5=CC=CC(C)=C5)=C(OC)C=C4)=C3.[Br-]

Storage & Handling

Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Quality Guarantee

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Key Properties

No computed properties available.

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Protocol Information

FXR agonist 3 (orb1982428)

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Available Sizes

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1 mg
$ 140.00
1 ml x 10 mM (in DMSO)
$ 640.00