FPR Agonist 43

SKU: orb1706571

Description

FPR Agonist 43 is a synthetic small molecule that simultaneously activates both formyl peptide receptor 1 (FPR1) and FPR2/ALX. This dual agonist is a valuable research tool for investigating receptor-specific signaling, immune cell chemotaxis, and inflammation in both cellular and animal models of disease.

Key Properties

• CAS Number: 903895-98-7
• MW: 384.86
• Purity: 99.60% (May vary between batches)
• Formula: C₂₀H₂₁ClN₄O₂
• SMILES: CC(C)c1c(NC(=O)Nc2ccc(Cl)cc2)c(=O)n(-c2ccccc2)n1C
• Target: Others
• Solubility: DMSO:34.2 mg/mL (88.86 mM);10% DMSO+90% Corn Oil:2 mg/mL (5.2 mM)

Bioactivity

• In Vitro:
  FPR Agonist 43 (10-5-107 nM) is actively potent in the cAMP assay in FPR2/ALX over-expressing CHO cells. FPR Agonist 43 is also active in the GTPγ binding assay (IC50=207±51 nM). FPR1 is the preferred receptor for FPR Agonist 43 in in both human neutrophils and possibly also in mouse cells.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

FPR Agonist 43, FPR1, FPR2/ALX

Compound Identifiers

PubChem CID

24776341