Duloxetine hydrochloride

SKU: orb1308539

Description

Duloxetine hydrochloride is an (S)-enantiomer thiophene derivative that acts as a selective serotonin and norepinephrine reuptake inhibitor (SNRI). It is utilized in research as an antidepressant and anxiolytic agent and for studying neuropathic pain mechanisms in models of diabetes and fibromyalgia, supporting both in vitro and in vivo experimental applications.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 136434-34-9
• MW: 333.88
• Purity: >99.99% (May vary between batches)
• Formula: C₁₈H₂₀ClNOS
• SMILES: s1cccc1[C@@H](Oc1cccc2c1cccc2)CCNC.Cl
• Target: Dopamine Receptor,Norepinephrine,5-HT Receptor,Serotonin Transporter
• Solubility: Ethanol:< 1 mg/mL (insoluble or slightly soluble);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.99 mM);DMSO:250 mg/mL (748.77 mM)

Bioactivity

• Target IC50:
  SNRI:4.6 nM(Ki)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, Noradrenaline transporter (Sodium-dependent), musculoskeletal, pain, LY248686, LY-248686, LY-248686 HCl, LY248686 Hydrochloride, LY-248686 hydrochloride, LY-248686 Hydrochloride, LY 248686, LY 248686 Hydrochloride, osteoarthiritis, Inhibitor, generalized, DA transporter, depressive, Dopamine Receptor, Duloxetine, Duloxetine HCl, Duloxetine Hydrochloride, Duloxetine hydrochloride, disorder, DopamineReceptor, (S)-Duloxetine, (S)-Duloxetine hydrochloride, 5HTReceptor, 5-HTT, 5HT Receptor, anxiety, SLC6A4, Serotonin Transporter, SerotoninTransporter, SERT, Sert (Sodium-dependent)

Compound Identifiers

PubChem CID

60834