Dryocrassin ABBA

SKU: orb1302330

Description

Dryocrassin ABBA is a bioactive flavonoid isolated from Dryopteris crassirhizoma. It exhibits documented antiviral and antibacterial properties, making it a compound of interest for pharmacological research in infectious diseases, with studies conducted both in vitro and in vivo.

Research Area

Cell Biology, Infectious Disease & Virology

Key Properties

• CAS Number: 12777-70-7
• MW: 820.83
• Purity: 98.92%
• Formula: C₄₃H₄₈O₁₆
• SMILES: CCCC(=O)c1c(O)c(CC2=C(O)C(C)(C)C(O)=C(C(C)=O)C2=O)c(O)c(Cc2c(O)c(CC3=C(O)C(C)(C)C(O)=C(C(C)=O)C3=O)c(O)c(C(=O)CCC)c2O)c1O
• Target: Apoptosis,Influenza Virus,Antibacterial
• Solubility: DMSO:10 mM;10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (1.22 mM)

Bioactivity

• In Vitro:
  Dryocrassin ABBA and its analogues (b5 and e2) showed better NAs inhibitory activity against Anhui H7N9 with IC values of 3.6 μM, 2.5 μM and 1.6 μM. For the highly resistant Shanghai N9, these compounds can also show medium inhibitory activities. Docking results indicated the direct interaction of synthesized 3 hits with the key K294 by hydrogen bonds, but no direct interaction of OSV with the key K294 was observed in Shanghai N9. dryocrassin ABBA and its analogues especially AB, which consisted of polyphenol groups may have beneficial effects on treating avian influenza H7N9 virus.

Storage & Handling

• Storage: store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Bacterial, Bcl-2, Caspase, Dryopteris crassirhizoma, Dryocrassin, Dryocrassin ABBA, H5N1, p53, InfluenzaVirus, Influenza Virus, Influenza virus, immunostimulatory function, IL Receptor, Staphylococcus aureus, TNF-α

Compound Identifiers

PubChem CID

3082025