Deoxyvasicinone

SKU: orb1684653

Description

Deoxyvasicinone is a natural alkaloid with inhibitory activity against eukaryotic translation, SUMOylation, and 15-human lipoxygenase (15-LOX). This multi-target profile makes it a valuable research tool for studying protein synthesis, post-translational modifications, and inflammation-related pathways in both cellular and biochemical assays.

Research Area

Metabolism Research, Protein Biochemistry

Key Properties

• CAS Number: 530-53-0
• MW: 186.21
• Formula: C₁₁H₁₀N₂O
• SMILES: O=C1C=2C=CC=CC2N=C3N1CCC3
• Target: Lipoxygenase,E1/E2/E3 Enzyme
• Solubility: DMSO:40 mg/mL (214.81 mM);10% DMSO+40% PEG300+5% Tween-80+45% Saline:1.5 mg/mL (8.06 mM)

Bioactivity

• Target IC50:
  HepG2 cells:5.7 μM|MCF-7 cells:7.21 μM|HCC827 cells:0.75μM
• In Vitro:
  Methods: Deoxyvasicinone (0-100 μM) was used to treat human liver cancer cells (HepG2), human breast cancer cells (MCF7) and human lung cancer cells (HCC827), and CCK8 was used to determine cytotoxicity. Results: The IC50 values ​​of deoxyvasicinone against HepG2, MCF7 and HCC827 were 5.7, 7.21 and 0.75 μM, respectively.

Storage & Handling

• Storage: keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Deoxyvasicinone, 9-Oxodeoxypeganine, Pegenone

Compound Identifiers

PubChem CID

68261