Cyclovirobuxine D

SKU: orb1304784

Description

Cyclovirobuxine D (Bebuxine) is a natural bioactive alkaloid isolated from Buxus microphylla. It is utilized in cardiovascular research, with studies investigating its pharmacological effects in both in vitro assays and in vivo experimental models.

Research Area

Cell Biology, Signal Transduction

Key Properties

• CAS Number: 860-79-7
• MW: 402.66
• Purity: 97.78% (May vary between batches)
• Formula: C₂₆H₄₆N₂O
• SMILES: [H][C@]1([C@H](C)NC)[C@H](O)C[C@@]2(C)[C@]3([H])CC[C@]4([H])[C@]5(C[C@@]35CC[C@]12C)CC[C@H](NC)C4(C)C
• Target: Apoptosis,Autophagy,Akt,mTOR
• Solubility: H2O:Insoluble;Ethanol:13 mg/mL (32.29 mM);DMSO:Insoluble

Bioactivity

• In Vivo:
  Cyclovirobuxine D facilitates the utilization of intracellular Ca(2+) and prevents its efflux, thereby exerting protective effects against heart failure. It enhances the vitality of cardiomyocytes damaged by oxidation or hypoxia. Furthermore, it significantly reduces the infarct size caused by ligation of the coronary artery in rats. Cyclovirobuxine D also protects the endothelial cells of rat aortas from hypoxic damage and increases the release of NO within these cells.
• In Vitro:
  The LD50 of Cyclovirobuxine D in mice is found to be 8.9 mg/kg (i.v.), 9.2 mg/kg (i.p.), and 293 mg/kg (p.o.). This compound is observed to reduce the weight of venous thrombosis in rats. In anesthetized pigs, Cyclovirobuxine D initiates coronary vasodilation, a mechanism associated with the release of nitric oxide in endothelial cells. Furthermore, it also improves cardiac failure induced by myocardial infarction in rats.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Akt, Autophagy, Apoptosis, Bebuxine, CVB-D, Cyclovirobuxin D, Cyclovirobuxine D, Inhibitor, Mammalian target of Rapamycin, mTOR, inhibit, PKB, Protein kinase B

Compound Identifiers

PubChem CID

260439