COR659

SKU: orb1303954

Description

COR659 is a 2-acylaminothiophene derivative that functions as a GABAB receptor positive allosteric modulator and a cannabinoid CB1 receptor antagonist/inverse agonist. It has been shown to reduce alcohol and chocolate self-administration in rodent models, supporting its use in preclinical research on addiction and reward-related behaviors.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 544450-68-2
• MW: 337.82
• Purity: 99.56%
• Formula: C₁₆H₁₆ClNO₃S
• SMILES: CCc1c(C)sc(NC(=O)c2ccc(Cl)cc2)c1C(=O)OC
• Target: Cannabinoid Receptor,GABA Receptor
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.92 mM);DMSO:33.33 mg/mL (98.66 mM)

Bioactivity

• In Vivo:
  COR659 (0, 2.5, 5, and 10 mg/kg) treatment is completely ineffective on lever-responding (FR10) for regular food pellets in food-deprived Wistar rats. However, COR659 suppresses lever-responding for a sucrose solution in sP rats and a chocolate solution in Wistar rats. Animal Model: Male sP and Wistar rats.
• In Vitro:
  COR659 exerts its effects through a composite mechanism, including positive allosteric modulation of the GABAB receptor and action at the cannabinoid CB1 receptor .

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

COR659, COR-659, COR 659, chocolate, CB1, Cannabinoid Receptor, CannabinoidReceptor, alcohol, GABA Receptor, GABAReceptor, GABAB, Gamma-aminobutyric acid Receptor, Inhibitor, inhibit, sucrose, γ-Aminobutyric acid Receptor

Compound Identifiers

PubChem CID

897320